Clomiphene increases gonadotropin-releasing hormone in the body by affecting the hypothalamus, leading to increased secretion of follicle-stimulating hormone and luteinizing hormone. For clomiphene to be effective, a woman\’s estrogen levels must remain normal. If the ovaries are functioning properly, the hypothalamus and pituitary gland can secrete hormones. If it is not during the menstrual period, it is necessary to induce the onset of menstruation. Clomiphene is particularly effective in women with hypothalamic/pituitary gland dysfunction.
Clomiphene is usually available as a 50 mg tablet to be taken daily, continuously each cycle 5 days. Start taking it on the 3rd, 4th or 5th day after menstruation. Approximately 50% of women who are eligible for this treatment are able to ovulate at a dose of 50 mg per day. For the other 25% of women, ovulation will not occur until the daily dose is increased to 100 mg. This drug should not be used for more than 3 to 6 cycles. After the third cycle, the efficacy of clomiphene begins to decrease. If pregnancy does not occur after 6 cycles of taking clomiphene, your doctor should look for other possible causes of infertility and discuss alternative medical treatments.
In most cases, ovulation occurs 5 to 12 days after the last dose of clomiphene. To increase the chance of pregnancy, after the 10th day of menstruation, the couple should have sex frequently (for example, every other day) or use an ovulation test kit to find the best time to have sex. A blood test or ultrasound can be used to determine ovulation.
If treatment with clomiphene alone still fails to induce ovulation, it can be used in combination with other drugs to enhance the effect. One of the most common methods is to inject human chorionic gonadotropin. Gonadotropins stimulate the gonads, a woman\’s ovaries. When a woman\’s own endocrine system is not working, gonadotropins from menopausal women may be used to promote follicle development in addition to taking clomiphene. In some cases, the development of the follicles is checked using ultrasound, and when the follicles reach more than 20 millimeters in shape, an injection is performed. Clomiphene can also be used in combination with glucose steroid drugs, such as prednisone, for women who have elevated levels of the adrenal androgen dehydroepiandrosterone and are unable to ovulate while taking clomiphene normally. Ovulation and pregnancy probability. For women who do not respond strongly to either clomiphene or gonadotropin therapy, a combination of the two drugs can sometimes be effective in triggering ovulation.
The main function of clomiphene is to induce ovulation. For infertility caused by anovulation, the application of clomiphene can increase the chance of ovulation, thereby achieving the purpose of pregnancy. In addition, it has a certain effect on polycystic ovary syndrome, anovulatory functional uterine bleeding, frequent menstruation, premature ovulation, luteal insufficiency and other diseases. However, clomiphene directly stimulates the ovaries. If the dosage is too large and the use time is too long, the ovaries can become extremely enlarged and even rupture, causing massive bleeding and accidents. \”A medicine is three parts poisonous\”, and clomiphene is no exception. It can cause mild damage to liver function. Patients with a history of hepatitis should use it with caution. Once abnormal liver function occurs, the drug must be stopped immediately. Since the main function of clomiphene is to promote ovulation, there is no need or inability to use clomiphene in cases of infertility other than ovulation disorders. Even if there is ovulation disorder, the decision of whether to use clomiphene or not must be made by the doctor and not by one\’s own discretion. The factors of infertility are complex and multifaceted. Without detailed examination and detailed laboratory tests, it is very dangerous to take clomiphene indiscriminately once infertility occurs.
Clinical treatment shows that taking clomiphene will cause adverse reactions. The miscarriage rate after taking clomiphene during pregnancy is 15% to 25%, which is similar to the miscarriage rate caused by other treatments for infertile couples. The incidence of congenital defects did not differ between fertile and fertile couples. More common adverse reactions include fever in 20% of women and ovarian enlargement in 15% of women. A small number of women experience abdominal discomfort, usually caused by swollen ovaries. Other adverse reactions that are not serious but cause significant discomfort include extreme mood swings, breast tenderness, headache, nervousness, dizziness, nausea, vomiting and fatigue. Women taking the drug should stop taking clomiphene and contact their doctor if they feel visual interference, such as blurred vision or blind spots.
In addition , treatment with clomiphene increases the probability of having multiple births. About 8% of women taking clomiphene gave birth to twins, and less than 1% gave birth to triplets. Since clomiphene is widely used in clinical treatment, the number of triplets born is considerable.
This article is provided by Baidu Reading and is excerpted from \”The Clear \”Conception\” Plan\” Author: Sun Jianqiu and Xie Yingbiao