Medical research believes that the causes of male infertility are complex and multifaceted. Certain drugs used to treat diseases can also cause sperm formation disorders in men, thereby causing male infertility.
How do drugs cause male infertility? Thereason is that certain drugs can directly inhibit the cell division of the seminiferous tubules in the testis and hinder the formation of normal sperm cells; Certain drugs can indirectly interfere with the sperm production function of the testicles through hormones by inhibiting the human body\’s diencephalon-pituitary system. As for the former, the use of nitrofuran, dichloroacetamide, thiophene and other drugs can prevent the protein synthesis of spermatogonia and primary spermatocytes. Even if the dosage is commonly used, it will also inhibit the spermatogenesis function. effect. According to relevant information, certain drugs with a hydroxyl compound structure, such as chlorambucil and cyclophosphamide, can inhibit the spermatogenesis function, and it is difficult to return to normal even if the drugs are stopped. Many anti-cancer drugs, whether used alone or in combination, can affect spermatogenesis to varying degrees. For example, the use of vincristine inhibits the synthesis of mRNA (the \”messenger\” transmitted from the genetic residence in the cell) and impairs protein synthesis. The spermatogenesis function stagnates the division of spermatogonia, primary spermatocytes and sperm cells in the testis; however, the Leydig cells in the testis are normal. This kind of damage is different from hydroxyl compounds, and the degree of damage to cells is relatively mild. Once the drug is stopped, the spermatogenesis function can return to normal. Cimetidine, used to treat ulcers, can block the normal activity of androgen receptors and cause abnormal sperm production.
As for drugs that affect pituitary function, the use of monoamine oxidase inhibitors can reduce the secretion of gonadotropins from the pituitary gland. Extensive use of steroid hormones, such as testosterone, progesterone, and androgens, can also indirectly inhibit spermatogenesis.
There are many drugs that can affect men’s spermatogenic function, and they are closely related to factors such as the combination, dosage, and duration of use of the drugs. What is easily overlooked by people is that excessive use of aspirin, vitamin B12, vitamin E, etc. can also inhibit the sperm production function, so attention should be paid to it.
For couples preparing for pregnancy and childbirth, special attention should be paid to the following drugs that can induce infertility:
(1) Cimetidine is used to treat duodenal ulcers or upper gastrointestinal bleeding. Long-term use of this drug may cause a temporary reduction in male sperm and infertility. p>
(2) Cyclophosphamide, used to treat multiple myeloma, etc., as daily dosage for adults When it reaches 6 to 10 grams, it can cause a significant reduction in the number of male sperm, or even no sperm at all; if used by women, it can also cause amenorrhea or menstrual disorders.
(3) Sulfasalazine, used to treat ulcerative tuberculosis, can lead to adverse reactions such as lack of semen, reduced sperm count, and reduced motility.
(4) Co-trimoxazole, used to treat urinary tract infections, respiratory infections, tonsillitis, etc., can induce a decrease in sperm count.
(5) Drugs that can induce infertility include: thyroid preparations, which can cause women to stop ovulating.The diuretic spironolactone and the antipsychotic drug methylthiodine Azine, etc., can also cause amenorrhea or menstrual disorders, or even endocrine disorders.
This article is provided by Baidu Reading and is excerpted from \”The Clear \”Conception\” Plan\” Author: Sun Jianqiu and Xie Yingbiao