Case: After five years of marriage, they are crazy about having children. “You don’t know, we want children very much, but I don’t know why, we have never been pregnant.” Hu Li (pseudonym) and Zhong Cheng (pseudonym) have been married for 5 years. gave birth. During multiple examinations, the doctor told them that they had no organic problems and comforted them by saying, \”Don\’t worry, just wait.\” Until recently, both men had been diagnosed with immune deficiencies. pregnant.
Hu Li told reporters that she and her husband got married on May 1, 2000. At first, they did not want to have children too early, so they usually took birth control pills to prevent pregnancy. The couple wanted to have a child, but couldn\’t stand the old man\’s urging, so they planned to have a child. \”Basically, starting from the second year after marriage, we didn\’t take any measures when we got married. I always thought it would be soon.\” I could get pregnant, but my belly never moved. \”A year and a half later, Hu Li and her husband began to feel anxious.
\”Which one of us has a problem?\” Hu Li\’s husband first questioned. Under such circumstances, Zhong Cheng first went to a hospital in Nanjing for a semen analysis without telling his family. The results found that his sperm count, motility, and fallopian tube quality were all very good. At this time, the husband cast his doubtful eyes on his wife. Although Hu Li felt aggrieved, she still came to the hospital anxiously and went to the hospital for a fallopian tube test. When the flow was complete, the doctor told her \”good, no problem with ovulation.\”
This result puzzled the couple, but the doctor who examined them said, \”The problem is not serious. You are still young. Let\’s take a look later.\” They were relieved.
Half a year passed quickly. By the end of 2003, the two had been married for more than three years, but Hu Li\’s belly still didn\’t move. ——No problem as before at the hospital. The hospital concluded it was unexplained infertility.
\”In the past few years, we have prayed to God and Buddha, but we couldn\’t get pregnant.\” After June this year, the two went to the Provincial People\’s Hospital for a comprehensive examination. \”The examination items were very careful, and in the end the doctor said that we have immune infertility. It is said that my body has produced antibodies against my husband\’s sperm, so there is no way to form a fertilized egg, so naturally I \”cannot have children.\” Now we are getting treatments to break down this antibody. \”
Cause: The antibodies produced by the wife kill the husband\’s sperm. The sperm may inhibit the sperm from combining with the egg to form a fertilized egg, or prevent the fertilized egg from growing healthily in the uterus.
Ying Xiaoyan explained that male semen and the sperm contained in it are inherently antigenic substances, but male sperm has a natural immune evasion function. Under normal circumstances, the mucosa of the female reproductive tract is intact and has no lesions. Absorbs the antigens contained in sperm. At this time, the male\’s sperm can rely on this immune evasion function to easily pass through the female\’s cervical barrier and combine with the egg to form a fertilized egg.
\”However, when the male reproductive organs and female reproductive tract mucosa are damaged or infected, that is, when various inflammations occur, this natural barrierBarrier protection will be weakened or even lost. At this time, semen and sperm antigens can enter the body and stimulate the female body to produce antibodies (including anti-sperm antibodies). When the sperm comes in again, the antibodies may directly kill it as the number one enemy, even if there are antibodies that form fertilized eggs. It is also difficult to develop into an embryo.
Experts from the Department of Obstetrics and Gynecology of the Provincial People\’s Hospital told reporters that the incidence of gynecological inflammation is increasing, and many of them are immune. Increase.
Delayed pregnancy can also lead to infertility. Gynecologists from many hospitals including Gulou Hospital, Provincial Hospital of Traditional Chinese Medicine, and Municipal First Hospital told reporters that in clinical practice they encountered couples who had been married for many years but had no children. When they checked it out medically, everything was fine. At the same time, if the man\’s sperm is removed and subjected to certain anti-allergic treatment and experimental means, the man\’s sperm and the woman\’s egg can form a normal fertilized egg. Some of them may be immune infertile patients.
Ying Xiaoyan told reporters that many young people in the city did not want children when they first got married. This situation also provides a breeding ground for the occurrence of immune infertility. \”When two people just start having sexual relations, the pregnancy rate in the first month of marriage is as high as 22%-24%, because men\’s semen and sperm contain immune evasion functions. The drug has the same properties, and some women will produce sperm-targeted drugs. Antibody.\”
At the same time, the reporter learned during the interview that women with excessive and chaotic sexual life are more likely to develop various inflammations, and therefore are more likely to cause immune infertility.
Treatment: Avoid \”contact\” with rejection antibodies. \”Is there no way to cure immune infertility?\” Regarding the reporter\’s doubts, whether the expert\’s answer is yes, Xie Jingyan, deputy chief physician of the Department of Obstetrics and Gynecology of Nanjing First Hospital, told reporters, \”Immune infertility does not mean that you must not be able to get pregnant. At the same time, if you are diagnosed with immune infertility, you can use medication to desensitize it.\”
Chief physician Ying Xiaoyan told reporters that there is a simple and effective way to get rid of immune infertility in real life, which is to wear condoms during sexual intercourse to avoid direct contact with the woman\’s semen (including sperm). genitals. After one year, after the anti-sperm antibodies in the woman\’s body have decreased or disappeared, semen can enter the vagina directly. At this time, the sperm can successfully combine with the egg and lead to pregnancy.
Attached: Diagnostic criteria for immune infertility (1) Infertility period exceeds 3 years;
(2) Exclude other causes of infertility;
(3) Reliable detection methods confirm the presence of anti-fertility antibodies in the body;
(4) In vitro experiments confirmed that anti-fertility immunity interferes with human sperm-egg fusion.
Among the above 4 criteria, if the first 3 are met, immune infertility can be clinically diagnosed, and if 4 of them are met at the same time, the clinical diagnosis can be confirmed.
