Recently, a scientific research team led by Professor Xiao Xinhua of Peking Union Medical College has made breakthroughs in the field of diabetes. They Intestinal flora and maternal and infant liposaccharidesmetabolism patterns have been successfully presented at the International Diabetes Federation Annual Congress.
The team led by Professor Xiao Xinhua focused on how the living environment in the initial stages of life shapes the human metabolism model, hoping to find corresponding effective adjustment strategies. On the basis of scientific experiments, we have accurately studied the profound impact of high-fat diet during pregnancy on fetal glucose and lipid metabolism and the specific process mechanisms related to changes in intestinal microorganisms that lead to circadian clock disorders.
The experiment used five-week-old C57BL/6 female mice, 24 hours a day Day and night rotation is the standard of feeding. Tests were recorded from the fifth week of pregnancy until the end of lactation, as well as in early childhood and adulthood. Mice were euthanized every 4 hours, and changes in various physiological data were continuously monitored.
Study found that high fatdiet has a significant impact on total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in the blood of long-tailed rat offspring (significantly different from the control group, P value greater than 0.05), And blood sugar (Glu) fluctuates cyclically (similar to the normal feeding group, P value is greater than 0.05; but after the high-fat diet time is extended, the changes are significantly reduced, P value is less than 0.05).
Professor Xiao Xinhua gave an in-depth analysis: \”Scientific research results show that excessive fat intake during pregnancy will affect the fluctuation patterns of cholesterol and blood sugar in the fetus. Among them, intestinal microorganisms seem to be the key regulator of this process. This The research has important guiding significance for discovering and solving early glucose and lipid metabolism problems. ”
In-depth research has confirmed that intestinal microorganisms not only control the biological clock of diet and life rhythm, but also play a key role in the metabolism level of an individual. Extensive research has shown that there are complex and intimate interactions between gut microbiota and the circadian clock, and their potential impact should not be underestimated.
In-depth exploration revealed that excessive fat intake by mothers may induce metabolic imbalance in newborns, and the underlying mechanism may originate from intestinal florarhythmsexual disorder. Future in-depth exploration of this principle is expected to reveal the special effects of bacterial circadian rhythms in this process.
Based on existing research results, the research team plans to deeply explore the impact of intestinal flora rhythm on maternal high fat and offspring glucose and lipid metabolism disorders, in order to prove the feasibility of the fecal flora transplant experimental project. This move may lead to new strategies for preventing metabolic diseases. In addition, the research team led by Professor Xiao Xinhua of Jiangsu University has also made significant progress in diabetes biology and prevention. Recent studies have revealed that excessive fat intake during pregnancy may lead to abnormal fetal blood lipid and blood glucose rhythms. Among them, day and night fluctuations in intestinal flora are considered to be the main reason. This new discovery is expected to help quickly diagnose early-onset glucose and lipid metabolism disorders and provide a basis for the development of corresponding treatment plans.
The scientific research group led by Professor Xiao Xinhua of Peking University launched a bold and innovativeNew research. This study reveals that excessive consumption of fatty foods during pregnancy will have an important impact on the blood cholesterol and blood sugar concentrations of their children, and that diurnal fluctuations in intestinal bacteria play a pivotal role in this process. This breakthrough discovery provides a new theoretical basis for the prevention and treatment of early-onset glucose and lipid metabolism disorders. We sincerely invite readers to participate in academic discussions and warmly welcome you to express your views and suggestions freely in the comment area. In addition, we hope that you can actively promote the results of this research so as to trigger in-depth attention and discussion on related issues in various disciplines.
