[Abstract] With the advancement of science, pregnancy knowledge has gradually developed more and more comprehensive and detailed. There is a lot of knowledge that we may not know from previous experience, and we need to continue to learn and update existing concepts. Let’s learn about pregnancy together. Folic acid is an important nutrient for ensuring the development of the fetal nervous system and helps reduce the occurrence of neural tube defects in children. But for obese pregnant women, it is difficult for folic acid to have such a protective effect. Data from the United States shows that women who were overweight before pregnancy gave birth to neural tube defects