Causes Fallopian tube blockage is usually caused by: infection, fibroblasts, and ectopia. Infection: Pelvic infection is the leading cause of fallopian tube blockage. Repeated infections can lead to inflammation of the fallopian tubes, leading to adhesions at the inflammatory site and ultimately luminal atresia. Fibroblast hyperplasia: The tissue surrounding the fallopian tubes is stimulated to form a large number of fibroblasts. These cells will gradually proliferate and produce scar tissue, leading to narrowing or occlusion of the fallopian tube lumen. Ectopia: Ectopia is a common gynecological condition that can lead to blockage of the fallopian tubes. Ectopia is when the endometrium grows outside the uterus