Instructions for use of the nine-valent HPV vaccine The nine-valent HPV vaccine is an effective way to prevent cancers and diseases caused by the human papillomavirus (HPV). Although the vaccine is very effective in preventing disease, not everyone can receive it. Here, we will explain in detail the list and contents of contraindications of the nine-valent HPV vaccine. Contraindications 1: Allergy to the components of the nine-valent HPV vaccine. The nine-valent HPV vaccine contains many ingredients and additives.