Down syndrome screening Differences between male and female babies Down syndrome screening is a common prenatal screening method, used to detect whether the baby has Down syndrome and other chromosomal abnormalities. Down syndrome screening is most often used to detect Down syndrome, although it can also be used to detect other chromosomal abnormalities. The disease knows no age, gender, region or race, so accurate diagnosis is crucial. The following will explain the differences between male and female babies, interpretation and analysis of Down syndrome screening results, and common