What are the early symptoms of hand, foot and mouth disease? Hand, foot and mouth disease is a common infectious disease, and children are the most susceptible group to this disease. The initial symptoms of hand, foot and mouth disease are similar to influenza. If detected early and active treatment measures can be taken, the condition can be effectively alleviated and the patient\’s pain reduced. The following are the specific manifestations of the early symptoms of hand, foot and mouth disease: 1. Fever Fever is the earliest and most common symptom of hand, foot and mouth disease. Within 3 to 5 days after infection, the patient\’s body temperature will gradually rise and fever will appear in varying degrees. Patients with low fever usually have a temperature of 37.5-38