What is foot and mouth disease? Hand, foot and mouth disease is a common childhood infectious disease, mainly caused by certain enteroviruses, including EV71, CoxsackieA16, CoxsackieA5, CoxsackieA10, etc. It usually occurs in summer and autumn and is easily spread in places where high-density crowds gather, such as kindergartens and nurseries. Symptoms and transmission methods of hand, foot and mouth disease. First of all, the incubation period of hand, foot and mouth disease is generally 3-7 days. During the incubation period, children may be asymptomatic or have mild fever, fatigue and other reactions, but these are not easy to detect.