Guide to Preparing for Pregnancy with Anal Fissure: How to Prepare for Pregnancy Successfully and Avoid Discomfort? Anal fissure refers to a disease in which the skin and mucous membrane around the rectum develops cracks or ulcers, often accompanied by symptoms such as anal pain, blood in the stool, and discomfort during defecation. For couples who are trying to conceive, anal fissures may have a negative impact on sexual intercourse.