1. Causes of high alanine aminotransferase in pregnant women There are many reasons for high alanine aminotransferase in pregnant women. Common ones include hepatitis B virus infection, drug overdose or abuse, autoimmune hepatitis, etc. During pregnancy, due to changes in hormone levels and an increase in metabolic rate, the burden on the liver increases, which can easily lead to an increase in alanine aminotransferase. two