How long into pregnancy do you have the strongest reaction? Pregnancy is a very important stage for every woman. During this stage, the body will have a series of reactions, which often make many women who have not become mothers very worried. So, how early in pregnancy is the strongest reaction? This article will introduce this issue from four aspects and give suggestions for relieving discomfort during pregnancy. 1. What is the strongest period of reaction? The most intense pregnancy response is roughly between 5 and 8 weeks of pregnancy, when progesterone surges, including progesterone, estrogen, human chorionic gonadotropin, and human chorionic luteinizing hormone. During this period, most women