What is Down syndrome screening? Down syndrome screening is the process of checking whether the fetus has Down syndrome (DownSyndrome). Down syndrome is a common congenital disease, usually caused by chromosomal abnormalities. Patients usually have typical facial contours and delayed intellectual development. For couples and pregnant women who are preparing for pregnancy, Down syndrome screening is one of the necessary prenatal examinations so that they can understand the treatment plan as early as possible. How much does Down\’s syndrome screening cost? The cost of Down\’s syndrome screening varies by region and hospital. It is generally 300.