What is ovulation goo? Ovulation goo refers to the thicker, gooey substance that appears in vaginal secretions during a woman\’s ovulation period. It is a manifestation of the gradual maturation of follicles in the ovary and the release of eggs into the fallopian tube under the action of ovarian gonadotropins and progesterone. The more typical characteristic of sticky substances during ovulation is that they appear in threads or clumps in dry air.