What is acne caused by endocrine disorders? Endocrine disorders refer to imbalances in hormone secretion in the endocrine system that cause certain abnormal reactions in the body, including skin problems such as acne, oily skin, etc. Therefore, long-term endocrine imbalance can lead to the formation of acne. How to cure acne? 1. Drug treatment: such as topical and oral antibiotics, retinoic acid drugs, etc. These drugs have obvious effects in controlling sebum secretion and killing Propionibacterium acnes.