Lupus Symptoms Lupus is an autoimmune disease that typically presents with skin symptoms and involvement of multiple organs throughout the body. The most common lupus symptom is a \”butterfly\” rash, a red or purple rash that appears on the bridge of the nose and sides of the cheeks. In addition, patients may also experience skin symptoms such as pain, swelling, and purple discoloration of the fingers and toes, oral ulcers, and hair loss. If fever, fatigue