Instructions for Premarin Premarin is a beauty and skin care product specially designed for female friends. Its main ingredients are hydrolyzed collagen and hyaluronic acid. It is designed to improve skin elasticity and moisturizing, and help women have healthier and younger skin. Below are detailed instructions for using Premarin. Instructions for use 1. Clean face: Use cleansing products to clean facial skin and wash with water. 2. Use a cotton pad to apply Premarin Essence