What is Lupus? Lupus is an autoimmune disease that causes the body\’s immune system to attack its own organs and tissues, leading to chronic inflammation and tissue damage that can affect multiple organ systems. The cause is not yet fully understood, but both genetic and environmental factors may play a role. Skin manifestations of early symptoms When lupus erythematosus attacks, the skin is often one of the first organs affected. Early skin symptoms can include: red spots on the face (known as \”butterfly spots\”) that are shaped