Factors affecting sperm antibody content Sperm antibody content refers to the content of anti-sperm antibodies in the male reproductive system. The level of sperm antibodies will directly affect male fertility. So, what are the factors that influence sperm antibody content? 1. Sperm quantity The sperm quantity will directly affect the sperm antibody content. When the sperm count is low, the antigenic substances in the sperm mix with the prostatic fluid and ejaculate secreted by the seminal vesicles, which will stimulate the production of a large amount of antibodies. 2. Having sex too frequently. Having sex too frequently can also lead to an increase in sperm antibody levels. this