The Difference Between Urticaria and Eczema Urticaria and eczema are both skin diseases, but they have different symptoms and different treatments. In daily life, we tend to confuse the two. Therefore, this article will introduce the differences between the two in terms of skin lesion manifestations, causes, classification, treatment methods, etc. Differences in manifestations of skin lesions: Urticaria appears as papules and plaques on the skin, which are usually larger, irregular in shape, and have clear borders.