What is confinement disease and confinement disease joint pain? Confinement sickness is a physical discomfort that women may experience for a period of time after giving birth. Postpartum disease is related to endocrine changes in the body, the physical burden of pregnancy and postpartum blood loss. Postpartum disease has many symptoms, including postpartum joint pain. Postpartum disease joint pain refers to the superposition of changes in hormone levels and physiological pain in women after childbirth.