The difference between quadruple vaccine and pentavalent vaccine When parents vaccinate their children, they will face the problem of choosing quadruple vaccine or pentavalent vaccine. The quadruple vaccine includes diphtheria-tetanus pertussis, polio, diphtheria and tetanus vaccines, while the pentavalent vaccine also adds Haemophilus type B vaccine. So what are the differences between the quadruple vaccine and the pentavalent vaccine? First of all, the pentavalent vaccine will be more expensive than the quadruple vaccine. Secondly, the pentavalent vaccine