What is the difference between Down syndrome screening and non-invasive prenatal testing? Prenatal check-up is a very important process that can help pregnant women understand the health of their fetus. Nowadays, there are many common prenatal check-up methods on the market, among which Down syndrome screening and non-invasive prenatal check-up are two of the more common ones. So, what\’s the difference between the two? How should we choose prenatal check-up methods? The difference between Down\’s syndrome screening and non-invasive prenatal testing mainly lies in the method, accuracy and scope of application. First of all, Down syndrome screening is a method that detects three markers in the serum of pregnant women.