What is the drug Clomiphene? Clomiphene (Clomiphene), also known as progesterone preparation, is an ovulation drug. Clomiphene is an estrogen receptor modulator used to stimulate ovarian ovulation and as an assisted reproductive treatment in some cases of infertility. It is often used in combination with artificial insemination and in vitro fertilization technology based on whether the female fallopian tube is unobstructed and the male sperm quality. Clomiphene is generally used for major ovulatory disorders such as polyovulation