I want to have children after marriage, but it’s like I’m under an evil spell.
Ms. Qin from Nanjing miscarried quickly once she became pregnant. She had six miscarriages in three years, each time before 12 weeks, about 84 days old. She was diagnosed with recurrent miscarriage. The whole family was in pain because they could never save their child. After diagnosis at the Nanjing Maternal and Child Health Hospital, it was suspected that it was related to the similarity of the couple\’s HLA genes, which resulted in the mother\’s inability to produce a blocking antibody that protects the embryo. 
Reasons why couples are prone to miscarriage if their genes are similar
1. The mother cannot produce blocking antibodies to protect the embryo, which makes the embryo susceptible to interference from the external environment.
2. During the combination of sperm and egg, due to the high genetic similarity, damage and mutation can easily occur, resulting in the formation of mutant embryos.
3. Due to the high genetic similarity, the mother cannot distinguish between normal embryos and abnormally mutated embryos, and loses their protection and causes spontaneous abortion.
The genetic similarity between husband and wife causes the mother to be unable to produce blocking antibodies that protect the embryo. 
The relationship between couples’ HLA gene similarity and the mother’s inability to produce blocking antibodies to protect the embryo
HLA gene is the most important part of the human leukocyte antigen system, which determines our body’s immunity The ability of the system to respond to external invading substances (such as bacteria, viruses, etc.). When the HLA genes between husband and wife are more similar, it is difficult for the mother to distinguish which \”enemies\” she carries, and thus cannot form a protective shield to protect the embryo.
In fact, 75% of miscarriages are caused by chromosomal variations! As women age, the chance of chromosomal variation and structural variation in a woman\’s eggs increases. Therefore, chromosomal variation can easily lead to miscarriage during pregnancy.
There is also a correlation between a history of recurrent miscarriage and immune factors predisposing to miscarriage. Recurrent miscarriage refers to the occurrence of natural cessation or early natural death after two or more consecutive natural pregnancies, and immune factors account for all possible causes.important location.
In view of the problem of miscarriage caused by genetic similarity, we can take some solutions to reduce the risk: for example, assisted reproductive technology, eugenics and other methods can help solve this problem. Scientific methods can reduce the risk of miscarriage due to genetic similarity and provide more opportunities for babies to be born safely into this world.
