What is the relationship between polycystic ovary and insulin resistance
Polycystic disease is ultimately an endocrine disorder. I saw a post before that said insulin resistance means that insulin secretion is sufficient or even exceeds the standard but does not work. But at the same time, high levels of insulin can thicken the walls of the ovaries, preventing them from expelling follicles well. Over time, the number of follicles stored in the ovaries increases. It becomes something more. Additionally, estrogen itself may be low, so the follicles fail to mature. My fasting glucose tolerance is normal, but my insulin is excessive, which is typical resistance. Doctors say there is currently no good solution for PCOS. During this stage, taking dimethylmethacan will lower blood sugar and insulin secretion may be reduced. Obese people are prone to hormone disorders, and hormone disorders are more likely to lead to obesity. This is a vicious cycle.
Is there a relationship between high insulin and polycystic ovary
Insulin is an important hormone that controls blood sugar in the body. Increased insulin does not cause polycystic ovaries, which are prone to hyperinsulinemia.
Polycystic ovaries can affect reproductive function and can easily be combined with hyperinsulinemia, obesity, acne and other diseases. At this time, hyperinsulinemia is only a component or manifestation of polycystic ovary syndrome, indicating the existence of insulin resistance in the body and the need for drug treatment to improve insulin resistance. Improving insulin resistance is also a treatment for polycystic ovary syndrome. 
[Extended information 】
1. Insulin is a protein hormone secreted by islet cells in the pancreas when stimulated by endogenous or exogenous substances such as glucose, lactose, ribose, arginine, and glucagon. . Insulin is the only hormone in the body that lowers blood sugar and blood sugar. Also promotes the synthesis of glycogen, fat and protein. Exogenous insulin is mainly used to treat diabetes. Insulin was first discovered by Canadian F.G. in 1921. Banting and C.H. Best. It began to be used clinically in 1922 to save patients with diabetes that could not be cured in the past. Head of the Institute of Nephrology Detection, Chinese Academy of Sciences. Until the early 1980s, nearly all insulin used in clinical trials was derived from pig and cow pancreas. The composition of insulin varies from animal to animal. The structures of pig and human insulin are most similar, with only one amino acid at the carboxyl end of the B chain differing. In the early 1980s, genetic engineering technology successfully produced human insulin in large quantities from microorganisms and applied it clinically.
2. In the early 1970s, British and Chinese scientists successfully determined the three-dimensional structure of porcine insulin using X-ray diffraction. These jobs areThis laid the foundation for in-depth study of the relationship between insulin molecular structure and function. People use full chemical synthesis and semi-synthetic methods to prepare analogues to study the impact of structural changes on biological functions; conduct comparative studies on different types of insulin; study abnormal insulin molecular diseases, that is, due to mutations in the insulin gene, the occurrence of individual amino acids in the insulin molecule These studies also have important practical implications for elucidating the causes of some forms of diabetes.
3. The gene controlling insulin synthesis is located on the short arm of chromosome 11. If the gene is normal, the insulin produced will have a normal structure; if the gene is mutated, the insulin produced will have an abnormal structure and is a mutant insulin. In the nucleus of the cell, the DNA in the insulin gene region on the short arm of chromosome 11 is transcribed into mRNA. The mRNA moves from the nucleus to the endoplasmic reticulum of the cytoplasm and is translated into preproinsulin consisting of 105 amino acid residues. Preproinsulin removes its propeptide through proteolysis to generate a long peptide chain of 86 amino acids, namely proinsulin (45343345). Proinsulin enters the Golgi apparatus with microvesicles in the cytoplasm. By the action of proteolytic enzymes, the chain connected to the three arginines 75, 55 and 6075 is severed. This chain is destroyed, producing useless C-peptide. At the same time, insulin is produced and secreted. to the outside of the cell and into the blood circulation. A small part of proinsulin that has not been hydrolyzed by proteases enters the blood circulation with insulin, and its biological activity is only 5% of insulin.
Will PCOS have insulin resistance?
Insulin resistance means that the biological efficiency of insulin is lower than normal. Insulin resistance reduces the sensitivity of peripheral tissues to insulin. About half of women with PCOS develop some degree of insulin resistance because with insulin resistance, the body compensates and secretes more insulin. Therefore, clinically, metformin hydrochloride is usually used in patients with obesity or insulin resistance. In addition, biguanide can inhibit hepatic glucose synthesis and increase the sensitivity of peripheral tissues to insulin.
What to do about Insulin Resistance
If a test shows insulin resistance, PCOS cannot be ruled out. It can also easily lead to the occurrence of diabetes. It is recommended that you go to the hospital to take blood tests for 6 sex hormones and do a color ultrasound to see if there are polycystic changes in the ovaries. If polycystic ovary syndrome is diagnosed, Diane 35 can be taken orally for anti-hormone treatment, or metformin can be taken to treat insulin resistance.
Insulin resistance and whether both polycystic and lean polycystic tumors have insulin resistance? After reading this article, will you be inspired? I hope this article has certain reference value for your work and study! For more articles about insulin resistance and whether polycystic and lean polycystic patients will develop insulin resistance, you can read further reading! Thank you for your attention and support!
